Chemistry Weekly Seminar - Curtis Rieder, Gilead Sciences

Title

Deceivingly Simple Origins – Identification and Mitigation of Safety Hazards in the Synthesis of API Starting Materials

Abstract

Every synthetic process begins with starting materials of relatively simple chemical structures. For small deliveries, these come from a vendor’s catalogue and we rarely think about how they are made in the first place. By overlooking these origin stories, we’re not necessarily aware of the potential safety risks involved in their synthesis. In securing a robust supply of these seemingly basic building blocks, safety is of the utmost importance and must be built-in throughout the development lifecycle. This presentation will explore ways in which potential hazards are identified and studied, and how that information shapes development and safety controls. The discussion will highlight case studies for different hazard scenarios encountered in a manufacturing setting, underscoring the demand for vigilance when scaling up processes, as well as introducing process development at Gilead Alberta.

Date:    Friday, January 20

Time:    1:30 pm

Place:    HLTH GB06