Chemistry Seminar - Akam Salih, PhD Candidate
Akam Salih, PhD Candidate in the Department of Chemistry will present a seminar at 10:00 am via Zoom.
Topic: Development of Chelators for Enhancing Radiometal-based Radiopharmaceuticals
Zirconium-89 has emerged as the most suitable radionuclide to pair with large macromolecules such as antibodies (immunoPET) for molecular imaging applications because it has a relatively long half-life that matches the biological half-life of most antibodies, favorable decay properties for positron emission tomography (PET), and efficient and affordable cyclotron production and purification. However, there are concerns related to its insufficient stability with desferoxamine B (DFO), the “gold standard” chelator in preclinical studies. Therefore, my work is focused on design, synthesis and evaluation of novel high denticity (8-12) desferrioxamine based ligands/chelators for zirconium-89 and potentially other high valent therapeutic radiometals.
Date: Friday, August 5
Time: 10:00 am
Zoom link available upon request to chem.dept@usask.ca