News & Events

 

Chemistry Weekly Seminar - Kelly Summers

Posted on 2018-01-09 in Events
Jan 19, 2018



Title:

8-HYDROXYQUINOLINES IN THE TREATMENT OF DISEASE

Alzheimer’s Disease (AD) is among the most prevalent and debilitating of over 40 different incurable human diseases associated with misfolding of a specific protein or peptide.  Despite the large volume of research that has focused on understanding Alzheimer’s disease mechanisms and identifying possible treatments, the field remains divided on what causes the disease, and therefore, what aspect of disease pathology might be targeted to cure the disease.  One avenue of research hypothesizes that dyshomeostasis of brain metals such as copper, zinc, and iron is a key step in disease progression.  To this end, metal chelation therapy has been explored as a possible AD treatment.  Promising results with 8-hydroxyquinoline (8HQ) metal chelators, in both animals and humans, showed improvements in both cognition and memory.  Although these chelators have been postulated to restore brain metal ion homeostasis, their mechanism of action remains largely unknown.  To better determine the mechanism of action of 8HQ chelators, we investigated the solution structure of 8HQ Cu(II) complexes, as well as the Cu(II)-binding site in aggregated Aβ (one of the major components of plaques observed in AD brains), using synchrotron X-ray absorption spectroscopy (XAS).  We have also investigated metal ion distributions in mammalian brain tissue treated with 8HQs using Fourier transform infrared (FTIR) mapping and synchrotron X-ray fluorescence imaging (XFI).  Results from synchrotron techniques, and other more conventional techniques, suggest that PBT2 binds Cu(II) differently than other 8HQs.  Differences in Cu(II) binding may allow for different interactions with aggregated Aβ, which could have significant implications for the development of future disease treatments.

Back to News Listing

Related Articles

Chemistry Special Seminar - Dr. Mukund Jha

Posted on 2019-07-16

Dr. Mukhund Jha, Nipissing University, will present a special seminar at 10:30 a.m. in Thorvaldson 205A.


Chemistry Special Seminar - Dr. John Sorensen

Posted on 2019-07-08

Dr. John Sorensen, University of Manitoba, will present a special seminar at 10:30 am in Thorvaldson 205A.


Chemistry Special Seminar - Dr. Ashok Kakkar

Posted on 2019-07-04

Dr. Ashok Kakkar, McGill University, will present a special seminar at 10:00 a.m. in Thorvaldson 159.


Chemistry Special Seminar - Dr. Jean-Francois Morin

Posted on 2019-06-27

Dr. Jean-Francois Morin of Universite Laval will present a special seminar at 10:30 am in Thorvaldson 159.


Chemistry Special Seminar - Dr. Sanjai Kumar Pathak

Posted on 2019-06-14

Dr. Sanjai Kumar Pathak, Queens College and Graduate Center of CUNY, New York will present a special seminar.


Chemistry Special Seminar - Dr. Claude Spino

Posted on 2019-05-21

Dr. Claude Spino, Universite de Sherbrooke, will present a special seminar at 11:00 a.m. in Thorvaldson 159.