PIMS Applied Mathematics Seminar Series: A Model of Microtubule Organization in the Presence of Motor Proteins

PIMS Applied Mathematics Seminar Series

When: Thursday, February 2, 2017, 1:30 PM

Where: Room 165, Physics Building, 

Guest:     Dr. Gerda de Vries
                Department of Mathematical & Statistical Sciences
                University of Alberta

Title:     A Model of Microtubule Organization in the Presence of Motor Proteins

Abstract:
Microtubules and motor proteins interact in vivo
and in vitro to form higher-order structures such as
bundles, asters, and vortices. In vivo, the organization
of microtubules is connected directly to cellular processes such as cell division, motility,
and polarization. To address questions surrounding the mechanism underlying microtubule
organization, we have developed a system of integro-partial dierential equations
that describes the interactions between microtubules and motor proteins. Our model
takes into account motor protein speed, processivity, density, and directionality, as well as
microtubule treadmilling and re-organization due to interactions with motors. Our model
is able to provide a quantitative and qualitative description of microtubule patterning.
Simulations results show that plus-end directed motor proteins form vortex patterns at
low motor density, while minus-end directed motor proteins form aster patterns at similar
densities. Also, a mixture of motor proteins with opposite directionality can organize microtubules
into anti-parallel bundles such as are observed in spindle formation.

PDF of Poster: PIMS Gerda Feb 2 2017.pdf

Facebook Event: https://www.facebook.com/events/407028549633555/ 

Note, Dr. Gerda de Vries will be also giving a public talk on Friday Feb 3rd for the PIMS 20th anniversary celebration.